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J Biol Chem 288(27):1976019772
In Japan, dapagliflozin gained approvals for CKD with or without diabetes, and in 2025, Mitsubishi Tanabe launched CANALIA, the first once-daily oral combination of a DPP-4 inhibitor and an SGLT2 inhibitor
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This structural difference affects stability, bioavailability, and conversion requirements in the body
doi: 10.1016/j.dsx.2019.06.021 176 AldawsariMAlmadaniFAAlmuhammadiNAlgabsaniSAlamroYAldhwayanM
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